| 2021-08-14 15:00:11August 14, 2021 | St Ives Town  | 1 - 0 |  Alvechurch | 15:00:1115:00 | Southern Premier Central | N/A | Match Report |
| 2021-08-17 19:45:12August 17, 2021 | Needham Market  | 1 - 1 | St Ives Town | 19:45:1219:45 | Southern Premier Central | N/A | Match Report |
| 2021-08-21 15:00:59August 21, 2021 | Stourbridge  | 1 - 3 | St Ives Town | 15:00:5915:00 | Southern Premier Central | N/A | Match Report |
| 2021-08-28 15:00:02August 28, 2021 | St Ives Town | 0 - 4 |  Stratford Town | 15:00:0215:00 | Southern Premier Central | N/A | Match Report |
| 2021-08-30 15:00:47August 30, 2021 | Biggleswade Town  | 3 - 2 | St Ives Town | 15:00:4715:00 | Southern Premier Central | N/A | Match Report |
| 2021-09-04 15:00:33September 4, 2021 | Needham Market | 1 - 0 | St Ives Town | 15:00:3315:00 | The FA Cup | N/A | Match Report |
| 2021-09-07 19:45:53September 7, 2021 | St Ives Town | 0 - 1 |  Lowestoft Town | 19:45:5319:45 | Southern League Challenge Cup | N/A | Match Report |
| 2021-09-11 15:00:50September 11, 2021 | St Ives Town | 1 - 2 |  Tamworth | 15:00:5015:00 | Southern Premier Central | N/A | Match Report |
| 2021-09-14 19:45:47September 14, 2021 | St Ives Town | 2 - 2 | Lowestoft Town | 19:45:4719:45 | Southern Premier Central | N/A | Match Report |
| 2021-09-25 15:00:48September 25, 2021 | Banbury United  | 5 - 1 | St Ives Town | 15:00:4815:00 | Southern Premier Central | N/A | Match Report |
| 2021-09-28 19:45:24September 28, 2021 | St Ives Town | 1 - 3 |  Barwell | 19:45:2419:45 | Southern Premier Central | N/A | Match Report |
| 2021-10-02 15:00:40October 2, 2021 | Alvechurch | 1 - 1 | St Ives Town | 15:00:4015:00 | Southern Premier Central | N/A | Match Report |
| 2021-10-09 15:00:20October 9, 2021 | St Ives Town | 1 - 7 |  Royston Town | 15:00:2015:00 | Southern Premier Central | N/A | Match Report |
| 2021-10-12 19:45:10October 12, 2021 | Leiston  | 3 - 1 | St Ives Town | 19:45:1019:45 | Southern Premier Central | N/A | Match Report |
| 2021-10-19 19:45:03October 19, 2021 | St Ives Town | 1 - 0 |  Hitchin Town | 19:45:0319:45 | Southern Premier Central | N/A | Match Report |
| 2021-10-23 15:00:53October 23, 2021 | St Ives Town | 2 - 4 |  Hednesford Town | 15:00:5315:00 | Southern Premier Central | N/A | Match Report |
| 2021-10-30 15:00:59October 30, 2021 | St Ives Town | 0 - 2 | Needham Market | 15:00:5915:00 | The FA Trophy | N/A | Match Report |
| 2021-11-06 15:00:51November 6, 2021 | Coalville Town  | 3 - 0 | St Ives Town | 15:00:5115:00 | Southern Premier Central | N/A | Match Report |
| 2021-11-09 19:45:46November 9, 2021 | St Ives Town | 2 - 1 |  Redditch United | 19:45:4619:45 | Southern Premier Central | N/A | Match Report |
| 2021-11-16 19:45:36November 16, 2021 | Rushall Olympic  | 3 - 1 | St Ives Town | 19:45:3619:45 | Southern Premier Central | N/A | Match Report |
| 2021-11-20 15:00:16November 20, 2021 | St Ives Town | 2 - 7 |  Peterborough Sports | 15:00:1615:00 | Southern Premier Central | N/A | Match Report |
| 2021-11-23 19:45:22November 23, 2021 | St Ives Town | 2 - 2 |  Bromsgrove Sporting | 19:45:2219:45 | Southern Premier Central | N/A | Match Report |
| 2021-11-27 15:00:31November 27, 2021 | Lowestoft Town | 2 - 2 | St Ives Town | 15:00:3115:00 | Southern Premier Central | N/A | Match Report |
| 2021-12-04 15:00:42December 4, 2021 | St Ives Town | 2 - 1 | Banbury United | 15:00:4215:00 | Southern Premier Central | N/A | Match Report |
| 2021-12-11 15:00:36December 11, 2021 | Bromsgrove Sporting | 1 - 0 | St Ives Town | 15:00:3615:00 | Southern Premier Central | N/A | Match Report |
| 2021-12-18 15:00:37December 18, 2021 | Barwell | 4 - 5 | St Ives Town | 15:00:3715:00 | Southern Premier Central | N/A | Match Report |
| 2021-12-27 13:00:34December 27, 2021 | St Ives Town | 2 - 1 | Biggleswade Town | 13:00:3413:00 | Southern Premier Central | N/A | Match Report |
| 2022-01-01 15:00:43January 1, 2022 | AFC Rushden & Diamonds  | 4 - 0 | St Ives Town | 15:00:4315:00 | Southern Premier Central | N/A | Match Report |
| 2022-01-04 19:45:49January 4, 2022 | Nuneaton Borough  | 1 - 2 | St Ives Town | 19:45:4919:45 | Southern Premier Central | N/A | Match Report |
| 2022-01-15 15:00:29January 15, 2022 | Hitchin Town | 4 - 0 | St Ives Town | 15:00:2915:00 | Southern Premier Central | N/A | Match Report |
| 2022-01-18 19:45:37January 18, 2022 | St Ives Town | 4 - 0 |  Eynesbury Rovers | 19:45:3719:45 | Hunts Senior Cup | N/A | Match Report |
| 2022-01-29 15:00:28January 29, 2022 | Royston Town | 1 - 1 | St Ives Town | 15:00:2815:00 | Southern Premier Central | N/A | Match Report |
| 2022-02-01 19:45:56February 1, 2022 | Yaxley FC  | 0 - 8 | St Ives Town | 19:45:5619:45 | Hunts Senior Cup | N/A | Match Report |
| 2022-02-05 15:00:30February 5, 2022 | St Ives Town | 2 - 1 | Leiston | 15:00:3015:00 | Southern Premier Central | N/A | Match Report |
| 2022-02-22 19:45:05February 22, 2022 | St Ives Town | 1 - 1 | Needham Market | 19:45:0519:45 | Southern Premier Central | N/A | Match Report |
| 2022-02-26 15:00:10February 26, 2022 | St Ives Town | 2 - 3 | Coalville Town | 15:00:1015:00 | Southern Premier Central | N/A | Match Report |
| 2022-03-05 15:00:24March 5, 2022 | Redditch United | 1 - 0 | St Ives Town | 15:00:2415:00 | Southern Premier Central | N/A | Match Report |
| 2022-03-19 15:00:13March 19, 2022 | St Ives Town | 3 - 2 | Nuneaton Borough | 15:00:1315:00 | Southern Premier Central | N/A | Match Report |
| 2022-03-22 19:45:33March 22, 2022 | Hednesford Town | 2 - 1 | St Ives Town | 19:45:3319:45 | Southern Premier Central | N/A | Match Report |
| 2022-03-26 15:00:02March 26, 2022 | Peterborough Sports | 2 - 0 | St Ives Town | 15:00:0215:00 | Southern Premier Central | N/A | Match Report |
| 2022-04-02 15:00:51April 2, 2022 | St Ives Town | 3 - 2 | Rushall Olympic | 15:00:5115:00 | Southern Premier Central | N/A | Match Report |
| 2022-04-09 15:00:46April 9, 2022 | St Ives Town | 1 - 4 | Stourbridge | 15:00:4615:00 | Southern Premier Central | N/A | Match Report |
| 2022-04-16 15:00:39April 16, 2022 | Stratford Town | 0 - 3 | St Ives Town | 15:00:3915:00 | Southern Premier Central | N/A | Match Report |
| 2022-04-18 15:00:52April 18, 2022 | St Ives Town | 1 - 0 | AFC Rushden & Diamonds | 15:00:5215:00 | Southern Premier Central | N/A | Match Report |
| 2022-04-23 15:00:46April 23, 2022 | Tamworth | 1 - 1 | St Ives Town | 15:00:4615:00 | Southern Premier Central | N/A | Match Report |
| 2022-04-26 19:45:14April 26, 2022 | St Ives Town | 2 - 0 |  Godmanchester Rovers | 19:45:1419:45 | Hunts Senior Cup | N/A | Match Report |